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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-12-17
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pubmed:databankReference |
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pubmed:abstractText |
SOX proteins contain a conserved HMG-related DNA-binding domain. They fulfill essential functions during the development of animals. Mutations in several SOX genes have been implicated in human diseases. We present here a new set of PCR primers designed to amplify a broad range of SOX HMG-box sequences. These primers facilitated the cloning of several new SOX HMG boxes from human genomic DNA, revealing unexpected complexity of the SOX gene family.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
438
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9827568-Amino Acid Sequence,
pubmed-meshheading:9827568-Animals,
pubmed-meshheading:9827568-Cloning, Molecular,
pubmed-meshheading:9827568-Conserved Sequence,
pubmed-meshheading:9827568-DNA Primers,
pubmed-meshheading:9827568-DNA-Binding Proteins,
pubmed-meshheading:9827568-High Mobility Group Proteins,
pubmed-meshheading:9827568-Humans,
pubmed-meshheading:9827568-Mammals,
pubmed-meshheading:9827568-Mice,
pubmed-meshheading:9827568-Molecular Sequence Data,
pubmed-meshheading:9827568-Multigene Family,
pubmed-meshheading:9827568-Nuclear Proteins,
pubmed-meshheading:9827568-Phylogeny,
pubmed-meshheading:9827568-Polymerase Chain Reaction,
pubmed-meshheading:9827568-Recombinant Proteins,
pubmed-meshheading:9827568-Sequence Alignment,
pubmed-meshheading:9827568-Sequence Homology, Amino Acid,
pubmed-meshheading:9827568-Sex-Determining Region Y Protein,
pubmed-meshheading:9827568-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.
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pubmed:affiliation |
Human Molecular Genetic Group, Institut de Génétique Humaine, UPR CNRS 1142, Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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