Linked Life Data

9812868

Source:http://linkedlifedata.com/resource/pubmed/id/9812868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-1-5
pubmed:abstractText
The monoamine contents in microdialysate from rat brain before and after droperidol (DRO), a dopamine (DA) antagonist, enhanced electroacupuncture-induced analgesia (EA) were measured using techniques of in vivo microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-EC), so as to investigate the monoamine mechanism of the potentiating effect of DRO on acupuncture analgesia (AA). The results showed that the levels of DA and its metabolites homovanillic acid (HVA) in perfusate increased after EA (P < 0.05 or 0.01), and further increased after DRO + EA (P < 0.05 and 0.01, vs EA treatment). A significant decrease in norepinephrine (NE) content after EA (P < 0.01) was observed, but no further change after DRO + EA (P > 0.05, vs EA treatment). The contents of 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindole acetic acid (5-HIAA) we elevated after EA treatment, and a further elevation in 5-HT and 5-HIAA contents induced by DRO + EA was noted. The results in the present study suggest that DRO potentiated AA not only via antagonizing the activity of dopaminergic system, but also by coordinating the activities of other monoamines in the brain.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Alteration of monoamine contents in microdialysate following droperidol enhanced electroacupuncture].
pubmed:affiliation
State Key Laboratory of Medical Neuobiology, Shanghai Medical University.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't