Linked Life Data

9796834

Source:http://linkedlifedata.com/resource/pubmed/id/9796834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-1-12
pubmed:abstractText
Angiotensin, a vasoconstrictive peptide, is now known to be an agent of vascular oxidative stress, vascular growth and inflammation, and may directly influence the pathophysiology of coronary artery disease (CAD). The presence of angiotensin-converting enzyme (ACE) and angiotensin II have been demonstrated in vascular tissue, and these local substances are causally involved in the development of vascular lesions. Recent clinical trials in post-myocardial infarction reported that ACE inhibitor therapy reduces recurrent myocardial infarction and prevents cardiac enlargement. Long-term prospective trials are currently being conducted to examine the effects of ACE inhibitor therapy on coronary ischaemic events and coronary atherosclerosis. This paper reviews angiotensin's role in the pathophysiology of CAD and the mechanisms of ACE inhibitor effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19 Suppl J
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
J2-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Mechanism of protective effects of ACE inhibition on coronary artery disease.
pubmed:affiliation
Harvard Medical School and Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review