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pubmed:otherAbstract |
PIP: The clinical value of hormone determinations and functional tests is presented. In regard to cyclical disruptions, foremost the anovulatory cycle with secondary amenorrhea primarily in mind, the important evaluation is that of the estrogen-gestagen test, followed by a determination of the plasma gonadotropins. For ovarian insufficiency, differential diagnosis between the hypothalamus, hypophysis, or disruptions in the feedback systems are most important. The clomisphene test is the primary means of radioimmunological evaluation of amenorrhea. This test enables one to determine which of the 3 functions above are showing a negative response to chemical stimuli. These tests are of great value in diagnostics and are also useful in evaluating the effectiveness of therapy. The main polemic is over whether it is most useful to evaluate the total estsrogens or the individual fractions. The same problem exists for progesterone. The main indication for the determination of total estogens, or fractions of estrone, estradiol, as well as progesterone is developmental control of medical ovulation release. The therapy of sterility cases also falls into this category. The exact determination of estrogen contents is not always possible, however, making reliability questionable. But the varied nature of their functions and the cost factors involved must remain important in evaluating them.
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pubmed:articleTitle |
[Radioimmunoassay, its value in clinical use: LH, FSH, progesterone, estrone, estradiol, estriol].
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