| pubmed-article:9792703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C0388730 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9792703 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9792703 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:9792703 | pubmed:dateCreated | 1998-12-10 | lld:pubmed |
| pubmed-article:9792703 | pubmed:abstractText | Cyclin D expression is regulated by growth factors and is necessary for the induction of mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine kinases and causes the down-regulation of cyclin D and an Rb-dependent growth arrest in the G1 phase of the cell cycle. We find that the induction of D-cyclin expression by serum and its repression by herbimycin A are regulated at the level of mRNA translation. Induction of cyclin D by serum occurs prior to the induction of its mRNA and does not require transcription. Herbimycin A repression is characterized by a decrease in the synthetic rate of D-cyclins prior to changes in mRNA expression and in the absence of changes in the half-life of the protein. This effect on D-cyclin translation is mediated via a phosphatidylinositol 3-kinase (PI 3-kinase)-dependent pathway. PI 3-kinase inhibitors such as wortmannin and LY294002, and rapamycin, an inhibitor of FRAP/TOR, cause a decline in the level of D-cyclins, whereas inhibitors of mitogen-activated protein kinase kinase and farnesyltransferase do not. Cells expressing the activated, myristoylated form of Akt kinase, a target of PI 3-kinase, are refractory to the effects of herbimycin A or serum starvation on D-cyclin expression. These data suggest that serum induction of cyclin D expression results from enhanced translation of its mRNA and that this results from activation of a pathway that is dependent upon PI 3-kinase and Akt kinase. | lld:pubmed |
| pubmed-article:9792703 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9792703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9792703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9792703 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9792703 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:RosenNN | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:TsichlisP NPN | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:BellacosaAA | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:MalstromS ESE | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:GrimesH LHL | lld:pubmed |
| pubmed-article:9792703 | pubmed:author | pubmed-author:Muise-Helmeri... | lld:pubmed |
| pubmed-article:9792703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9792703 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:9792703 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9792703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9792703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9792703 | pubmed:pagination | 29864-72 | lld:pubmed |
| pubmed-article:9792703 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:meshHeading | pubmed-meshheading:9792703-... | lld:pubmed |
| pubmed-article:9792703 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9792703 | pubmed:articleTitle | Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. | lld:pubmed |
| pubmed-article:9792703 | pubmed:affiliation | Program in Cell Biology and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:9792703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9792703 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9792703 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9792703 | lld:pubmed |
