|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0004083,
umls-concept:C0025202,
umls-concept:C0030705,
umls-concept:C0031327,
umls-concept:C0060696,
umls-concept:C0076080,
umls-concept:C0205054,
umls-concept:C0348016,
umls-concept:C0442027,
umls-concept:C0555198,
umls-concept:C1561451,
umls-concept:C1707455
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1998-11-4
|
|
pubmed:abstractText |
Depletion of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AT) has been shown to increase tumor sensitivity to chloroethylnitrosoureas. Temozolomide (TMZ), an analogue of dacarbazine, can deplete AT, suggesting that it may be used to sensitize tumors to chloroethylnitrosoureas. However, the influence of nitrosoureas on the pharmacokinetics of TMZ is unknown, and a pilot study was performed to assess the pharmacokinetics of TMZ given via, various routes to 29 patients (27 malignant melanomas, 2 gliomas) with or without sequential administration of i.v. fotemustine.
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|
pubmed:commentsCorrections |
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
42
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
433-40
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9788568-Administration, Oral,
pubmed-meshheading:9788568-Adult,
pubmed-meshheading:9788568-Aged,
pubmed-meshheading:9788568-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9788568-Blood-Brain Barrier,
pubmed-meshheading:9788568-Brain Neoplasms,
pubmed-meshheading:9788568-Dacarbazine,
pubmed-meshheading:9788568-Female,
pubmed-meshheading:9788568-Glioma,
pubmed-meshheading:9788568-Hepatic Artery,
pubmed-meshheading:9788568-Humans,
pubmed-meshheading:9788568-Infusions, Intra-Arterial,
pubmed-meshheading:9788568-Infusions, Intravenous,
pubmed-meshheading:9788568-Male,
pubmed-meshheading:9788568-Melanoma,
pubmed-meshheading:9788568-Middle Aged,
pubmed-meshheading:9788568-Nitrosourea Compounds,
pubmed-meshheading:9788568-Organophosphorus Compounds
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Pharmacokinetics of temozolomide in association with fotemustine in malignant melanoma and malignant glioma patients: comparison of oral, intravenous, and hepatic intra-arterial administration.
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|
pubmed:affiliation |
Département de médecine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|
