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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 4
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pubmed:dateCreated |
1998-12-14
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pubmed:abstractText |
Crystals of human heparin binding protein (HBP) diffract to 1.1 A when flash-frozen at 120 K. The atomic resolution structure has been refined anisotropically using SHELXL96. The final model of HBP consists of 221 amino-acid residues of 225 possible, three glycosylation units, one chloride ion, 15 precipitant ethanol molecules and 323 water molecules. The structure is refined to a final crystallographic R factor of 15.9% and Rfree(5%) of 18.9% using all data. A putative protein kinase C activation site has been identified, involving residues 113-120. The structure is compared to the previously determined 2.3 A resolution structure of HBP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0907-4449
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
598-609
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9761855-Antimicrobial Cationic Peptides,
pubmed-meshheading:9761855-Binding Sites,
pubmed-meshheading:9761855-Blood Proteins,
pubmed-meshheading:9761855-Carrier Proteins,
pubmed-meshheading:9761855-Crystallization,
pubmed-meshheading:9761855-Crystallography, X-Ray,
pubmed-meshheading:9761855-Enzyme Activation,
pubmed-meshheading:9761855-Glycosylation,
pubmed-meshheading:9761855-Hot Temperature,
pubmed-meshheading:9761855-Humans,
pubmed-meshheading:9761855-Lipid A,
pubmed-meshheading:9761855-Models, Molecular,
pubmed-meshheading:9761855-Protein Conformation,
pubmed-meshheading:9761855-Protein Kinase C,
pubmed-meshheading:9761855-Protein Processing, Post-Translational,
pubmed-meshheading:9761855-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
Atomic resolution structure of human HBP/CAP37/azurocidin.
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pubmed:affiliation |
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark. solveig.karlsen@chem.uit.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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