| pubmed-article:9754926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0054493 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9754926 | lifeskim:mentions | umls-concept:C0643663 | lld:lifeskim |
| pubmed-article:9754926 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:9754926 | pubmed:dateCreated | 1998-12-7 | lld:pubmed |
| pubmed-article:9754926 | pubmed:abstractText | 2-Hydroxycarbazole was shown to induce Ca2+ release from skeletal muscle and cardiac muscle sarcoplasmic reticulum at concentrations between 100-500 microM. This release was blocked by both 1 mM tetracaine and 30 microM ruthenium red which inhibit the ryanodine receptor or by pre-treatment with 10 mM caffeine which depletes the ryanodine receptor-containing Ca2+ stores. This, in addition to the fact that 2-hydroxycarbazole has little effect on Ca2+ ATPase activity, indicates that it activates Ca2+ release through the ryanodine receptor. The apparent EC50 value for release from both skeletal muscle and cardiac muscle sarcoplasmic reticulum was approximately 200 microM and maximal release occurred at 400-500 microM, making it approximately 20 times more potent than caffeine. The dose-dependency in the extent of Ca2+ release induced by 2-hydroxycarbazole was also apparently highly cooperative for both preparations. That 2-hydroxycarbazole was able to mobilize Ca2+ from non-muscle cell microsomes and in intact TM4 cells (which contain ryanodine receptors), makes this compound a more potent and commercially available alternative to caffeine in studying the role of this intracellular Ca2+ channel in a variety of systems. | lld:pubmed |
| pubmed-article:9754926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9754926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9754926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9754926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9754926 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9754926 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9754926 | pubmed:author | pubmed-author:MichelangeliF... | lld:pubmed |
| pubmed-article:9754926 | pubmed:author | pubmed-author:MeznaMM | lld:pubmed |
| pubmed-article:9754926 | pubmed:author | pubmed-author:ToveyS CSC | lld:pubmed |
| pubmed-article:9754926 | pubmed:author | pubmed-author:LonglandC LCL | lld:pubmed |
| pubmed-article:9754926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9754926 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:9754926 | pubmed:volume | 354 | lld:pubmed |
| pubmed-article:9754926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9754926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9754926 | pubmed:pagination | 245-51 | lld:pubmed |
| pubmed-article:9754926 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:meshHeading | pubmed-meshheading:9754926-... | lld:pubmed |
| pubmed-article:9754926 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9754926 | pubmed:articleTitle | 2-Hydroxycarbazole induces Ca2+ release from sarcoplasmic reticulum by activating the ryanodine receptor. | lld:pubmed |
| pubmed-article:9754926 | pubmed:affiliation | School of Biochemistry, University of Birmingham, Edgbaston, UK. | lld:pubmed |
| pubmed-article:9754926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9754926 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9754926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9754926 | lld:pubmed |
