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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-9-22
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pubmed:abstractText |
We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD30,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Constant Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin D,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-56
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9729045-Antibodies, Monoclonal,
pubmed-meshheading:9729045-Antigens, CD30,
pubmed-meshheading:9729045-Antigens, CD40,
pubmed-meshheading:9729045-B-Lymphocytes,
pubmed-meshheading:9729045-CD40 Ligand,
pubmed-meshheading:9729045-Cytokines,
pubmed-meshheading:9729045-Down-Regulation,
pubmed-meshheading:9729045-Gene Expression Regulation,
pubmed-meshheading:9729045-Humans,
pubmed-meshheading:9729045-Immunoglobulin A,
pubmed-meshheading:9729045-Immunoglobulin Class Switching,
pubmed-meshheading:9729045-Immunoglobulin Constant Regions,
pubmed-meshheading:9729045-Immunoglobulin D,
pubmed-meshheading:9729045-Immunoglobulin E,
pubmed-meshheading:9729045-Immunoglobulin G,
pubmed-meshheading:9729045-Immunoglobulin Heavy Chains,
pubmed-meshheading:9729045-Immunoglobulin M,
pubmed-meshheading:9729045-Interleukin-12,
pubmed-meshheading:9729045-Interleukin-6,
pubmed-meshheading:9729045-Membrane Glycoproteins,
pubmed-meshheading:9729045-NF-kappa B,
pubmed-meshheading:9729045-NF-kappa B p50 Subunit,
pubmed-meshheading:9729045-Phenotype,
pubmed-meshheading:9729045-Promoter Regions, Genetic,
pubmed-meshheading:9729045-Receptors, Antigen, B-Cell,
pubmed-meshheading:9729045-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.
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pubmed:affiliation |
Department of Pathology, Cornell University Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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