pubmed-article:9714850 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0038880 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0032824 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0071074 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C1412082 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
pubmed-article:9714850 | lifeskim:mentions | umls-concept:C0038944 | lld:lifeskim |
pubmed-article:9714850 | pubmed:dateCreated | 1998-11-9 | lld:pubmed |
pubmed-article:9714850 | pubmed:abstractText | 1. We have examined the properties of intracellular nucleotide-mediated gating of K+ channel constructs composed of the sulphonylurea receptor 2B and the inwardly rectifying K+ channel subunits Kir6.1 and Kir6.2 (SUR2B/Kir6.1 and SUR2B/Kir6.2 complex K+ channels) heterologously expressed in human embryonic kidney (HEK) 293T cells. In the cell-attached form, both types of K+ channel were activated by pinacidil. 2. In inside-out (IO) patches, the SUR2B/Kir6.2 channels opened spontaneously and were inhibited by intracellular ATP (ATPi). Pinacidil attenuated the ATPi-mediated channel inhibition in a concentration-dependent manner. In contrast, the SUR2B/Kir6.1 channels required intracellular nucleoside di- or tri-, but not mono-, phosphates for opening. The potency of adenine, guanine or uracil nucleotides to activate SUR2B/Kir6.1 channels was enhanced by pinacidil. 3. In the presence of pinacidil, adenine and guanine, but not uracil, nucleotides exhibited bell-shaped concentration-dependent activating effects on SUR2B/Kir6.1 channels. This was due to channel inhibition caused by adenine and guanine nucleotides, which was unaffected by pinacidil. 4. From power density spectrum analysis of SUR2B/Kir6.1 currents, channel activation could be described by the product of two gates, a nucleotide-independent fast channel gate and a nucleotide-dependent slow gate, which controlled the number of functional channels. Pinacidil specifically increased the potency of nucleotide action on the slow gate. 5. We conclude that Kir6.0 subunits play a crucial role in the nucleotide-mediated gating of SUR/Kir6.0 complex K+ channels and may determine the molecular mode of pinacidil action. | lld:pubmed |
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pubmed-article:9714850 | pubmed:language | eng | lld:pubmed |
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pubmed-article:9714850 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9714850 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9714850 | pubmed:month | Sep | lld:pubmed |
pubmed-article:9714850 | pubmed:issn | 0022-3751 | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:YamadaMM | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:KondoCC | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:IijimaTT | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:HorioYY | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:KurachiYY | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:SatohEE | lld:pubmed |
pubmed-article:9714850 | pubmed:author | pubmed-author:RepunteV PVP | lld:pubmed |
pubmed-article:9714850 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9714850 | pubmed:day | 15 | lld:pubmed |
pubmed-article:9714850 | pubmed:volume | 511 ( Pt 3) | lld:pubmed |
pubmed-article:9714850 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9714850 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9714850 | pubmed:pagination | 663-74 | lld:pubmed |
pubmed-article:9714850 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:9714850 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9714850 | pubmed:articleTitle | Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil. | lld:pubmed |
pubmed-article:9714850 | pubmed:affiliation | Department of Pharmacology II, Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. | lld:pubmed |
pubmed-article:9714850 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9714850 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:9714850 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:10060 | entrezgene:pubmed | pubmed-article:9714850 | lld:entrezgene |
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