| pubmed-article:9702203 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1260969 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1882954 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9702203 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:9702203 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9702203 | pubmed:dateCreated | 1998-8-31 | lld:pubmed |
| pubmed-article:9702203 | pubmed:abstractText | Phosphoinositide 3-kinases (PI(3)K) are important regulators of receptor signaling cascades and intracellular membrane trafficking. To date, no protein domain has been identified that binds specifically to Ptdlns(3)P and thereby recruits/activates downstream effectors of Ptdlns(3)P signaling. Using an in vivo assay in yeast that detects Vps34 PI(3)K-dependent intracellular localization of a GFP reporter protein, and in vitro lipid-binding assays, we demonstrate that cysteine-rich RING domains of the FYVE finger subfamily bind specifically to Ptdlns phosphorylated exclusively at the D-3 position of the inositol ring. GFP-FYVE domain fusion proteins localized predominantly to membranes of endocytic compartments and required active Vps34 PI(3)K. Our data establish a molecular link between Vps34 PI(3)K and several FYVE domain-containing proteins (Vac1p, Vps27p) required for vacuolar/lysosomal protein trafficking. | lld:pubmed |
| pubmed-article:9702203 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9702203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9702203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9702203 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9702203 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:9702203 | pubmed:author | pubmed-author:EmrS DSD | lld:pubmed |
| pubmed-article:9702203 | pubmed:author | pubmed-author:BurdC GCG | lld:pubmed |
| pubmed-article:9702203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9702203 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:9702203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9702203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9702203 | pubmed:pagination | 157-62 | lld:pubmed |
| pubmed-article:9702203 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9702203 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9702203 | pubmed:articleTitle | Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. | lld:pubmed |
| pubmed-article:9702203 | pubmed:affiliation | Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093-0668, USA. | lld:pubmed |
| pubmed-article:9702203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9702203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9702203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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