Linked Life Data

9665588

Source:http://linkedlifedata.com/resource/pubmed/id/9665588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-13
pubmed:abstractText
Cerebellar granule cells (CGC) are amongst the most abundant neuronal cells in the mammalian central nervous system. In vitro, they undergo apoptosis when deprived of depolarizing concentrations of KCl, providing an interesting system to study neuronal apoptosis. Despite its significance, the intracellular mechanisms that follow an apoptotic insult are poorly understood. Bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, blocks cell death and apoptosis with an optimal concentration of 10 microM. Bisindolylmaleimide also blocks apoptosis up to 7 h after KCl deprivation, suggesting that it blocks a secondary process. Ro-31-8220, another PKC inhibitor, also blocks apoptosis, but it is less effective, probably due to its lack of specificity. A possible PKC role in increasing the transcription or activating protein(s) involved in neuronal apoptosis is proposed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1713-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Bisindolylmaleimide prevents cerebellar granule cells apoptosis: a possible role for PKC.
pubmed:affiliation
CNRS UPR-9023, Mecanismes Moleculaires des Communications Cellulaires, CCIPE, Montpellier, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't