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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1998-9-23
|
| pubmed:abstractText |
Endogenous opioid peptides and opiates like morphine produce their pharmacological effects through the membrane bound opioid receptors. These receptors belong to a superfamily of G-protein-coupled receptors, all of which possess seven membrane-spanning regions. Structure-activity relationship studies of opioids opened up new avenues for the pharmacological characterization of the opioid receptors. As a further advancement in this direction, molecular cloning has led to the identification of three different types of opioid receptors -- OP1 (delta), OP2 (kappa) and OP3 (mu) -- thereby supporting the results of earlier pharmacological studies which postulated their existence. The three opioid receptors are highly homologous. Consequent to the development of highly specific and selective agonists and antagonists, it was proposed that the three types of opioid receptors could be further categorized into different subtypes. However, the molecular biology data generated so far do not support the presence of the various subtypes of the three well-characterized opioid receptors. Recent strides towards the advancement of our knowledge relating to the molecular biology of these receptors have been reviewed in this article.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics,
http://linkedlifedata.com/resource/pubmed/chemical/Opioid Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1021-7401
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-97
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9650823-Animals,
pubmed-meshheading:9650823-Cloning, Molecular,
pubmed-meshheading:9650823-GTP-Binding Proteins,
pubmed-meshheading:9650823-Guinea Pigs,
pubmed-meshheading:9650823-Humans,
pubmed-meshheading:9650823-Ligands,
pubmed-meshheading:9650823-Mice,
pubmed-meshheading:9650823-Morphine,
pubmed-meshheading:9650823-Multigene Family,
pubmed-meshheading:9650823-Narcotic Antagonists,
pubmed-meshheading:9650823-Narcotics,
pubmed-meshheading:9650823-Opioid Peptides,
pubmed-meshheading:9650823-Rats,
pubmed-meshheading:9650823-Receptors, Opioid,
pubmed-meshheading:9650823-Recombinant Fusion Proteins,
pubmed-meshheading:9650823-Structure-Activity Relationship,
pubmed-meshheading:9650823-Substrate Specificity,
pubmed-meshheading:9650823-Terminology as Topic
|
| pubmed:articleTitle |
Molecular biology of opioid receptors: recent advances.
|
| pubmed:affiliation |
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India. vksingh@sgpgi.ren.nic.in
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|