Linked Life Data

9637039

Source:http://linkedlifedata.com/resource/pubmed/id/9637039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-7-31
pubmed:abstractText
Behavioral detection thresholds, auditory filter widths, and temporal modulation transfer functions were obtained from four starlings before, during and after 11 days of subcutaneous injections of kanamycin, an aminoglycoside antibiotic. Birds were operantly conditioned to respond to pure tones and amplitude modulated noises ranging in frequency from 0.25 to 7 kHz using adaptive staircase procedures and were tested daily for 92 days after the first injection of aminoglycoside. All birds had threshold shifts of at least -60 dB at frequencies above 4 kHz. Lower frequencies were affected in some birds, although none of the birds had hearing loss below 3 kHz. All four birds had wider auditory filters at 5 kHz immediately after the aminoglycoside series. Any changes in frequency resolution at frequencies below 5 kHz were slight, transitory, and rarely observed. Two of the four birds had permanently wider auditory filters at 5 kHz. Temporal modulation transfer functions were briefly affected in two birds during the time of greatest threshold shift. Recovery of detection thresholds began soon after the injections ceased and continued for approximately 60 days. Recovery in frequency resolution lagged behind auditory threshold by about 10 days. Normal temporal resolution was observed in the context of impaired intensity and frequency resolution. Changes in auditory threshold and frequency resolution were closely associated for all birds at 5 kHz, but were correlated with statistical significance in only two birds. Scanning electron microscopy was performed on all four birds after 90 days of recovery and confirmed that the extent of initial damage was consistent with the pattern of observed hearing loss.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0001-4966
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3567-80
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Auditory perception following hair cell regeneration in European starling (Sturnus vulgaris): frequency and temporal resolution.
pubmed:affiliation
Department of Speech and Hearing Sciences, University of Washington, Seattle 98195, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't