Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-7-9
pubmed:databankReference
pubmed:abstractText
Two-component histidine kinases recently have been found in eukaryotic organisms including fungi, slime molds, and plants. We describe the identification of a gene, COS1, from the opportunistic pathogen Candida albicans by using a PCR-based screening strategy. The sequence of COS1 indicates that it encodes a homolog of the histidine kinase Nik-1 from the filamentous fungus Neurospora crassa. COS1 is also identical to a gene called CaNIK1 identified in C. albicans by low stringency hybridization using CaSLN1 as a probe [Nagahashi, S., Mio, T., Yamada-Okabe, T., Arisawa, M., Bussey, H. & Yamada-Okabe, H. (1998) Microbiol. 44, 425-432]. We assess the function of COS1/CaNIK1 by constructing a diploid deletion mutant. Mutants lacking both copies of COS1 appear normal when grown as yeast cells; however, they exhibit defective hyphal formation when placed on solid agar media, either in response to nutrient deprivation or serum. In constrast to the Deltanik-1 mutant, the Deltacos1/Deltacos1 mutant does not demonstrate deleterious effects when grown in media of high osmolarity; however both Deltanik-1 and Deltacos1/Deltacos1 mutants show defective hyphal formation. Thus, as predicted for Nik-1, Cos1p may be involved in some aspect of hyphal morphogenesis and may play a role in virulence properties of the organism.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-1547504, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-1741614, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-2005825, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-2030668, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-2215421, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-5802619, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-6219280, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-6394957, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-6394964, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-791079, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-7992058, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8029829, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8083193, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8259520, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8349105, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8357339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8622950, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8808622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8917571, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-8917572, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9142740, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9155024, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9191038, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9259554, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9298905, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9442881, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9478896, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618540-9493379
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7069-73
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans.
pubmed:affiliation
Division of Biology 147-75, California Institute of Technology, Pasadena, CA 91125, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.