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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1998-7-7
|
| pubmed:abstractText |
Neurocan is a nervous tissue-unique chondroitin sulfate proteoglycan (CSPG) whose expression and proteolytic cleavage are developmentally regulated. In the adult rat brain, neurocan is completely cleaved into some proteoglycan fragments including the C-terminal half known as neurocan-C and a N-terminal fragment with a 130 kDa core glycoprotein (neurocan-130). We describe here the differential distribution of these two neurocan-derived CSPGs in the adult rat cerebrum and the occurrence of neurocan-130 as a new member of a perineuronal net-constituting molecule. At the light microscopic level, neurocan-130 exhibited pericellular localization around a subset of neurons in addition to diffuse distribution in the neuropil. In contrast, neurocan-C was distributed only diffusely in the neuropil. Double staining with anti-neurocan-130 and anti-synaptophysin antibodies suggested that neurocan-130 was localized in the vicinity of the synapses, but not at the synapses. Immunoelectron microscopy showed that neurocan-130 was mainly localized in the cytoplasm of glial cell processes, the so-called glial perineuronal net, encompassing the cell bodies of certain neurons. The presence of neurocan-130 in a limited number of glial cells may reflect some functional heterogeneity of the glia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfate Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NCAN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptophysin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
|
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
790
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
45-51
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9593817-Age Factors,
pubmed-meshheading:9593817-Animals,
pubmed-meshheading:9593817-Brain Chemistry,
pubmed-meshheading:9593817-Cerebral Cortex,
pubmed-meshheading:9593817-Chondroitin Sulfate Proteoglycans,
pubmed-meshheading:9593817-Hippocampus,
pubmed-meshheading:9593817-Lectins, C-Type,
pubmed-meshheading:9593817-Microscopy, Immunoelectron,
pubmed-meshheading:9593817-Neostriatum,
pubmed-meshheading:9593817-Nerve Tissue Proteins,
pubmed-meshheading:9593817-Neuroglia,
pubmed-meshheading:9593817-Neurons,
pubmed-meshheading:9593817-Neuropil,
pubmed-meshheading:9593817-Peptide Fragments,
pubmed-meshheading:9593817-Rabbits,
pubmed-meshheading:9593817-Rats,
pubmed-meshheading:9593817-Rats, Sprague-Dawley,
pubmed-meshheading:9593817-Synaptophysin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Occurrence of a N-terminal proteolytic fragment of neurocan, not a C-terminal half, in a perineuronal net in the adult rat cerebrum.
|
| pubmed:affiliation |
Department of Perinatology, Institute for Developmental Research, Kasugai, Aichi 480-0392, Japan. i45365u@nucc.cc.nagoya-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|