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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1998-7-9
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pubmed:abstractText |
After analyzing nonsatisfactory therapeutic results in the 1970s and early 1980s, the 81-01 treatment protocol of the Dana-Farber Cancer Institute was initiated in 1987 in the Children's Oncohaematology Clinic in Sofia, Bulgaria. Two hundred thirty patients were enrolled with a period of observation of a minimum of 14 and a maximum of 97 months; the median age was 5.83 +/- 3.6 years. According to the original criteria, standard risk (SR) patients were 38.26% and high-risk (HR) patients 61.74%. The probability for event-free survival at the seventh year estimated with the Kaplan-Meier method for the total group was 0.67 +/- 0.04 (+/- SE) and 0.55 +/- 0.09 and 0.81 +/- 0.06 for HR and SR, respectively (P < .001). Improvement of therapeutic results in terms of remission failures, early deaths, patients lost to follow-up, and rate of relapses is discussed.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
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pubmed:issn |
0888-0018
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
157-64
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9592842-Adolescent,
pubmed-meshheading:9592842-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9592842-Bulgaria,
pubmed-meshheading:9592842-Child,
pubmed-meshheading:9592842-Child, Preschool,
pubmed-meshheading:9592842-Disease-Free Survival,
pubmed-meshheading:9592842-Female,
pubmed-meshheading:9592842-Humans,
pubmed-meshheading:9592842-Infant,
pubmed-meshheading:9592842-Male,
pubmed-meshheading:9592842-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9592842-Recurrence,
pubmed-meshheading:9592842-Remission Induction
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pubmed:articleTitle |
A seven-years experience in treatment of childhood ALL in Bulgaria.
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pubmed:affiliation |
Children's Oncohaematology Clinic, University Hospital "Queen Johanna," Sofia, Bulgaria.
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pubmed:publicationType |
Journal Article,
Clinical Trial
|