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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6680
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pubmed:dateCreated |
1998-5-27
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pubmed:abstractText |
Interleukin-6 (IL-6) is a cytokine that was initially recognized as a regulator of immune and inflammatory responses, but it also regulates the growth of many tumour cells, including prostrate carcinoma. Overexpression of the growth-factor receptors ErbB2/neu and ErbB3 has been implicated in the neoplastic transformation of prostate carcinoma. Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. We also show that ErbB2 forms a complex with the gp130 subunit of the IL-6 receptor in an IL-6-dependent manner. This association is important because the inhibition of ErbB2 activity results in abrogation of IL-6-induced MAPK activation. Thus ErbB2 is a critical component of IL-6 signalling through the MAP kinase pathway. These data show how a cytokine receptor can diversify its signalling pathways by engaging with a growth-factor receptor kinase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-3,
http://linkedlifedata.com/resource/pubmed/chemical/SHC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Shc Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
393
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9590694-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9590694-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:9590694-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9590694-Enzyme Activation,
pubmed-meshheading:9590694-Humans,
pubmed-meshheading:9590694-Interleukin-6,
pubmed-meshheading:9590694-Male,
pubmed-meshheading:9590694-Phosphorylation,
pubmed-meshheading:9590694-Prostate,
pubmed-meshheading:9590694-Proteins,
pubmed-meshheading:9590694-Proto-Oncogene Proteins,
pubmed-meshheading:9590694-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9590694-Receptor, erbB-2,
pubmed-meshheading:9590694-Receptor, erbB-3,
pubmed-meshheading:9590694-Shc Signaling Adaptor Proteins,
pubmed-meshheading:9590694-Signal Transduction,
pubmed-meshheading:9590694-Tumor Cells, Cultured,
pubmed-meshheading:9590694-Tyrosine
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pubmed:year |
1998
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pubmed:articleTitle |
Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells.
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pubmed:affiliation |
Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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