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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-8-25
|
| pubmed:abstractText |
Several derivatives of lotoprednol etabonate (1), a soft corticosteroid antiinflammatory drug, are formed during the synthesis and sterilization process. Some of these contaminants of 1 result from side reactions taking place on the steroid ring C including oxidation, dehydration, chlorination and chlorohydroxylation. The products have been identified, synthesized, and fully characterized by 1H and 13C NMR spectroscopy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0039-128X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
193-201
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9589553-Androstadienes,
pubmed-meshheading:9589553-Anti-Inflammatory Agents,
pubmed-meshheading:9589553-Chromatography, High Pressure Liquid,
pubmed-meshheading:9589553-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9589553-Mass Spectrometry,
pubmed-meshheading:9589553-Steroids
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Chemistry of loteprednol etabonate and related steroids. II. Reactions at ring C and NMR structural studies of the resulting compounds.
|
| pubmed:affiliation |
Pharmos Corporation, Alachua, Florida 32615, USA.
|
| pubmed:publicationType |
Journal Article
|