| pubmed-article:9576751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0024296 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0282552 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0387687 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:9576751 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:9576751 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9576751 | pubmed:dateCreated | 1998-6-8 | lld:pubmed |
| pubmed-article:9576751 | pubmed:abstractText | The CC chemokines MIP-1alpha, MIP-1beta, and RANTES suppress replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5). However, the same chemokines can enhance HIV-1 replication in cultured macrophages. The net effect of chemokines on HIV-1 infection in intact lymphoid tissue, the major reservoir of HIV-1 in vivo, is unknown and unpredictable since the tissue contains both T lymphocytes and macrophages. Here we show that exogenous MIP-1alpha, MIP-1beta, and RANTES markedly suppressed replication of CCR5-tropic HIV-1 strains in blocks of human lymphoid tissue infected ex vivo. Moreover, endogenous MIP-1alpha, MIP-1beta, and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4-tropic but not CCR5-tropic HIV-1. Such an upregulation may contribute to the virus phenotype shift in the course of HIV disease in vivo. | lld:pubmed |
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| pubmed-article:9576751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9576751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9576751 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9576751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9576751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9576751 | pubmed:month | May | lld:pubmed |
| pubmed-article:9576751 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9576751 | pubmed:author | pubmed-author:MargolisL BLB | lld:pubmed |
| pubmed-article:9576751 | pubmed:author | pubmed-author:MurphyP MPM | lld:pubmed |
| pubmed-article:9576751 | pubmed:author | pubmed-author:GlushakovaSS | lld:pubmed |
| pubmed-article:9576751 | pubmed:author | pubmed-author:GrivelJ CJC | lld:pubmed |
| pubmed-article:9576751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9576751 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9576751 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:9576751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9576751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9576751 | pubmed:pagination | 1876-80 | lld:pubmed |
| pubmed-article:9576751 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9576751 | pubmed:meshHeading | pubmed-meshheading:9576751-... | lld:pubmed |
| pubmed-article:9576751 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9576751 | pubmed:articleTitle | Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines. | lld:pubmed |
| pubmed-article:9576751 | pubmed:affiliation | Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:9576751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9576751 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9576751 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9576751 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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