| pubmed-article:9547347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1384543 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1335280 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1706044 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1416859 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9547347 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9547347 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9547347 | pubmed:dateCreated | 1998-5-21 | lld:pubmed |
| pubmed-article:9547347 | pubmed:abstractText | Paired immunoglobulin-like receptor B (PIR-B) (p91) molecule has been proposed to function as an inhibitory receptor in B cells and myeloid lineage cells. We demonstrate here that the cytoplasmic region of PIR-B is capable of inhibiting B cell activation. Mutational analysis of five cytoplasmic tyrosines indicate that tyrosine 771 in the motif VxYxxL plays the most crucial role in mediating the inhibitory signal. PIR-B-mediated inhibition was markedly reduced in the SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 double-deficient DT40 B cells, whereas this inhibition was unaffected in the inositol polyphosphate 5'-phosphatase SHIP-deficient cells. These data demonstrate that PIR-B can negatively regulate B cell receptor activation and that this PIR-B-mediated inhibition requires redundant functions of SHP-1 and SHP-2. | lld:pubmed |
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| pubmed-article:9547347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9547347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9547347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9547347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9547347 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9547347 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9547347 | pubmed:author | pubmed-author:OnoMM | lld:pubmed |
| pubmed-article:9547347 | pubmed:author | pubmed-author:MaedaAA | lld:pubmed |
| pubmed-article:9547347 | pubmed:author | pubmed-author:TakaiTT | lld:pubmed |
| pubmed-article:9547347 | pubmed:author | pubmed-author:KurosakiTT | lld:pubmed |
| pubmed-article:9547347 | pubmed:author | pubmed-author:KurosakiMM | lld:pubmed |
| pubmed-article:9547347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9547347 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9547347 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9547347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9547347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9547347 | pubmed:pagination | 1355-60 | lld:pubmed |
| pubmed-article:9547347 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9547347 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9547347 | pubmed:articleTitle | Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. | lld:pubmed |
| pubmed-article:9547347 | pubmed:affiliation | Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan. | lld:pubmed |
| pubmed-article:9547347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9547347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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