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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1998-5-21
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pubmed:abstractText |
Paired immunoglobulin-like receptor B (PIR-B) (p91) molecule has been proposed to function as an inhibitory receptor in B cells and myeloid lineage cells. We demonstrate here that the cytoplasmic region of PIR-B is capable of inhibiting B cell activation. Mutational analysis of five cytoplasmic tyrosines indicate that tyrosine 771 in the motif VxYxxL plays the most crucial role in mediating the inhibitory signal. PIR-B-mediated inhibition was markedly reduced in the SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 double-deficient DT40 B cells, whereas this inhibition was unaffected in the inositol polyphosphate 5'-phosphatase SHIP-deficient cells. These data demonstrate that PIR-B can negatively regulate B cell receptor activation and that this PIR-B-mediated inhibition requires redundant functions of SHP-1 and SHP-2.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-1535455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-1732748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-2415625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-7531695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-7621077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-7629493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-7716523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-7945780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-8107887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-8137818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-8552190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-8805703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-8921851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-90108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9039776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9054430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9133416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9143696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9144225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9177155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9190115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9203413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9203414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9203415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9203417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9203421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9214625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9236201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9242674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9244303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547347-9285411
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Fc gamma receptor IIB,
http://linkedlifedata.com/resource/pubmed/chemical/INPPL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Pirb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1355-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9547347-Antigens, CD,
pubmed-meshheading:9547347-B-Lymphocytes,
pubmed-meshheading:9547347-Bone Marrow Cells,
pubmed-meshheading:9547347-Calcium,
pubmed-meshheading:9547347-DNA Mutational Analysis,
pubmed-meshheading:9547347-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9547347-Lymphocyte Activation,
pubmed-meshheading:9547347-Phosphoric Monoester Hydrolases,
pubmed-meshheading:9547347-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:9547347-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:9547347-Protein Tyrosine Phosphatases,
pubmed-meshheading:9547347-Receptors, Antigen, B-Cell,
pubmed-meshheading:9547347-Receptors, IgG,
pubmed-meshheading:9547347-Receptors, Immunologic,
pubmed-meshheading:9547347-Signal Transduction
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pubmed:year |
1998
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pubmed:articleTitle |
Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal.
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pubmed:affiliation |
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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