Linked Life Data

9526073

Source:http://linkedlifedata.com/resource/pubmed/id/9526073

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-6-10
pubmed:abstractText
In opiate naive longitudinal muscle myenteric plexus tissue, facilitation (GS-mediated) and inhibition (Gi-mediated) of adenylyl cyclase (AC) activity is observed in response to low (nM) and high (microM) concentrations of sufentanil, respectively. Following chronic in vivo exposure to morphine, previously inhibitory concentrations produce excitatory effects. The present study was undertaken to explore the potential relevance of AC isoform-specific regulation to the qualitative change in opioid responsiveness following chronic morphine. Following persistent activation of opiate receptors, levels of AC I mRNA remain unchanged but that of AC IV is significantly augmented (approximately 37%, P < 0.05). AC I and IV are differentially regulated by G alpha i and G beta gamma. The former is inhibited by G alpha i and G beta gamma whereas the latter is relatively insensitive to G alpha i and is stimulated by G beta gamma. Thus, an increase in AC IV mRNA could represent a shift from inhibitory to stimulatory opiate receptor-G protein signalling, as has been observed following chronic morphine. These results indicate that persistent activation of opiate receptors can induce selective changes in the abundance (activity) of AC isoforms. This could explain, in part, some of the adaptations that occur following chronic in vivo morphine exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Differential effect of chronic morphine on mRNA encoding adenylyl cyclase isoforms: relevance to physiological sequela of tolerance/dependence.
pubmed:affiliation
Department of Biochemistry, State University of New York, Health Sciences Center, Brooklyn 11203, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't