| pubmed-article:9517481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C0063717 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C1518294 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C1325331 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9517481 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9517481 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9517481 | pubmed:dateCreated | 1998-4-24 | lld:pubmed |
| pubmed-article:9517481 | pubmed:abstractText | Interleukin-6 (IL-6) on target cells binds to the specific IL-6 receptor (IL-6R) and subsequently induces homodimerization of the signal-transducing protein gp130. Cells which express gp130 but no IL-6R and which therefore do not respond to IL-6 can be stimulated by the complex of IL-6 and soluble IL-6R (slL-6R). Here we show that on rat pheochromocytoma cells (PC12), the combination of IL-6 and slL-6R but not IL-6 alone induces expression of c-fos, GAP-43 and neuron-specific enolase followed by neuron-specific differentiation and formation of a neuronal network. The differentiation was dose-and time-dependent and followed the same kinetics as nerve-growth factor (NGF)-induced differentiation. The responses of PC12 cells to IL-6/sIL-6R and NGF were additive, suggesting independent signaling pathways. We demonstrate that activation of gp130 generates a neuronal differentiation signal that is equivalent to and independent of trk/NGF receptor tyrosine kinase. Interestingly, the failure of IL-6 to induce differentiation of PC12 cells is not due to lack of surface expression of IL-6R as IL-6 alone triggered expression of GAP-43 mRNA and protein. We hypothesize that PC12 cells express more gp130 than IL-6R and that the extent of activated gp130 molecules determines the quality of the response. | lld:pubmed |
| pubmed-article:9517481 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9517481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9517481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9517481 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9517481 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:9517481 | pubmed:author | pubmed-author:LamyJJ | lld:pubmed |
| pubmed-article:9517481 | pubmed:author | pubmed-author:OttenUU | lld:pubmed |
| pubmed-article:9517481 | pubmed:author | pubmed-author:Rose-JohnSS | lld:pubmed |
| pubmed-article:9517481 | pubmed:author | pubmed-author:HergetTT | lld:pubmed |
| pubmed-article:9517481 | pubmed:author | pubmed-author:MärzPP | lld:pubmed |
| pubmed-article:9517481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9517481 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9517481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9517481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9517481 | pubmed:pagination | 2765-73 | lld:pubmed |
| pubmed-article:9517481 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9517481 | pubmed:meshHeading | pubmed-meshheading:9517481-... | lld:pubmed |
| pubmed-article:9517481 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9517481 | pubmed:articleTitle | Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. | lld:pubmed |
| pubmed-article:9517481 | pubmed:affiliation | I.Department of Medicine, Mainz University, Germany. | lld:pubmed |
| pubmed-article:9517481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9517481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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