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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5-6
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|
pubmed:dateCreated |
1998-4-16
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|
pubmed:abstractText |
In the course of screening for Ras function inhibitors from plant extracts, we isolated lycorine from a chloroform extract of Eucharis grandiflora leaves. Lycorine induced flat morphology in K-ras-NRK cells after treatment for 2-3 days, whereas its morphological effect on NRK cells was weaker. Lycorine was found to inhibit protein synthesis specifically in cultured K-ras-NRK cells. It also lowered the cellular amount of Ras in 2-3 days.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0378-6501
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
23
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
151-5
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|
pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:9515224-Alkaloids,
pubmed-meshheading:9515224-Amaryllidaceae Alkaloids,
pubmed-meshheading:9515224-Animals,
pubmed-meshheading:9515224-Cell Division,
pubmed-meshheading:9515224-Cell Transformation, Neoplastic,
pubmed-meshheading:9515224-Fibroblasts,
pubmed-meshheading:9515224-Genes, ras,
pubmed-meshheading:9515224-Phenanthridines,
pubmed-meshheading:9515224-Plant Extracts,
pubmed-meshheading:9515224-Plant Leaves,
pubmed-meshheading:9515224-Plants, Medicinal,
pubmed-meshheading:9515224-Rats
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Induction of flat morphology in K-ras-transformed fibroblasts by lycorine, an alkaloid isolated from the tropical plant Eucharis grandiflora.
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pubmed:affiliation |
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
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pubmed:publicationType |
Journal Article
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