Linked Life Data

9488260

Source:http://linkedlifedata.com/resource/pubmed/id/9488260

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pubmed-article:9488260pubmed:abstractTextTo evaluate the effects of activated protein C therapy in a rabbit model of meningococcal endotoxin-induced shock, we performed a prospective, blinded, placebo-controlled animal trial. Forty New Zealand White rabbits were challenged with intravenous meningococcal endotoxin (lipooligosaccharide) 100 microg/kg. Ten minutes before endotoxin challenge, animals were administered either activated protein C 1600 microg/mL (n = 20) or an equal volume of saline (n = 20) as an initial bolus. After endotoxin challenge, activated protein C treated animals were administered a continuous infusion of activated protein C 160 microg/kg/h and saline-treated animals were administered an equal volume infusion of saline. Both activated protein C treated and saline control animals demonstrated evidence of shock after endotoxin challenge; mean arterial pressure and serum bicarbonate significantly (p < .01) declined, and heart rate significantly (p < .01) increased from baseline. In activated protein C treated animals, mean plasma activated protein C activity was 5.69 microg/mL (+/- 3.2) 1 h after challenge, whereas plasma protein C activity was not detected in controls. Mean prothrombin and activated partial thromboplastin times were significantly (p < or = .01) prolonged compared with saline-treated controls. Other hematologic and chemical measurements did not differ between groups. Fifteen of 20 (75%) animals treated with activated protein C concentrate survived to 24 h, while 9 of 20 (45%) control animals survived to 24 h (p = .05). Those animals treated with activated protein C had improved survival, which corroborates the findings of early clinical studies in which replacement of protein C improved outcome.lld:pubmed
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pubmed-article:9488260pubmed:pagination138-42lld:pubmed
pubmed-article:9488260pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:9488260pubmed:year1998lld:pubmed
pubmed-article:9488260pubmed:articleTitleActivated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits.lld:pubmed
pubmed-article:9488260pubmed:affiliationDepartment of Medicine, Children's Hospital, Denver, Colorado 80218, USA.lld:pubmed
pubmed-article:9488260pubmed:publicationTypeJournal Articlelld:pubmed
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