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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-3-13
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pubmed:abstractText |
To study the antitumor activity of the combination immunotherapy with interleukin-12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF), a murine MmB 16 melanoma tumor model was used. Seven days after inoculation of MmB 16 melanoma cells into the footpad of the right hind limb, mice were treated with IL-12 and/or GM-CSF administered intratumorally for 7 consecutive days. IL-12 used both at a high (1 microg) and at a low (0.01 microg) dose per day produced retardation of tumor growth, although neither treatment resulted in any significant prolongation of the survival of tumor-bearing mice. GM-CSF did not by itself exert antitumor activity in this model; however, it potentiated antitumor effects of IL-12. In particular, survival of tumor-bearing mice treated with IL-12 (0.01 microg per day) and GM-CSF was significantly prolonged compared with that in mice treated with either IL-12 or GM-CSF alone.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1010-4283
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pubmed:author |
pubmed-author:DabrowskaAA,
pubmed-author:FeleszkoWW,
pubmed-author:G?owackaEE,
pubmed-author:GiermaszAA,
pubmed-author:Go?abJJ,
pubmed-author:HoserGG,
pubmed-author:JakóbisiakMM,
pubmed-author:KaceMM,
pubmed-author:KawiakJJ,
pubmed-author:KulchitskaL ALA,
pubmed-author:LasekWW,
pubmed-author:Stok?osaTT,
pubmed-author:ZagozdzonRR
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9486559-Animals,
pubmed-meshheading:9486559-Cell Division,
pubmed-meshheading:9486559-Cell Survival,
pubmed-meshheading:9486559-Drug Synergism,
pubmed-meshheading:9486559-Erythrocyte Count,
pubmed-meshheading:9486559-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9486559-Hindlimb,
pubmed-meshheading:9486559-Interleukin-12,
pubmed-meshheading:9486559-Leukocyte Count,
pubmed-meshheading:9486559-Macrophages, Peritoneal,
pubmed-meshheading:9486559-Melanoma, Experimental,
pubmed-meshheading:9486559-Mice,
pubmed-meshheading:9486559-Nitric Oxide,
pubmed-meshheading:9486559-Organ Size,
pubmed-meshheading:9486559-Platelet Count,
pubmed-meshheading:9486559-Recombinant Proteins,
pubmed-meshheading:9486559-Spleen,
pubmed-meshheading:9486559-Time Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Granulocyte-macrophage colony-stimulating factor potentiates antitumor activity of interleukin-12 in melanoma model in mice.
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pubmed:affiliation |
Department of Immunology, Institute of Biostructure, Medical School of Warsaw, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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