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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-11
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pubmed:abstractText |
Arterial hypoxia mediates cerebral arteriolar dilation primarily via mechanisms involving activation of ATP-sensitive K+ channels (K[ATP]), which we have shown to be sensitive to ischemic stress. In this study, we determined whether ischemia/reperfusion alters cerebral arteriolar responses to arterial hypoxia in anesthetized piglets. Since adenosine plays an important role in cerebrovascular responses to hypoxia, we also determined whether adenosine-induced arteriolar dilation is affected by ischemic stress. We tested the hypothesis that reductions in cerebral arteriolar dilator responses after ischemia would be proportional to the contribution of K(ATP) to hypoxia and adenosine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
222-7; discussion 227-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9445354-Adenosine,
pubmed-meshheading:9445354-Adenosine Triphosphate,
pubmed-meshheading:9445354-Administration, Topical,
pubmed-meshheading:9445354-Analysis of Variance,
pubmed-meshheading:9445354-Animals,
pubmed-meshheading:9445354-Anoxia,
pubmed-meshheading:9445354-Arterioles,
pubmed-meshheading:9445354-Brain,
pubmed-meshheading:9445354-Brain Ischemia,
pubmed-meshheading:9445354-Cerebral Arteries,
pubmed-meshheading:9445354-Cerebrovascular Circulation,
pubmed-meshheading:9445354-Female,
pubmed-meshheading:9445354-Glyburide,
pubmed-meshheading:9445354-Hypercapnia,
pubmed-meshheading:9445354-Hypoglycemic Agents,
pubmed-meshheading:9445354-Injections, Intravenous,
pubmed-meshheading:9445354-Intracranial Hypertension,
pubmed-meshheading:9445354-Male,
pubmed-meshheading:9445354-Potassium Channel Blockers,
pubmed-meshheading:9445354-Potassium Channels,
pubmed-meshheading:9445354-Purinergic P1 Receptor Antagonists,
pubmed-meshheading:9445354-Reperfusion,
pubmed-meshheading:9445354-Swine,
pubmed-meshheading:9445354-Theophylline,
pubmed-meshheading:9445354-Vasodilation,
pubmed-meshheading:9445354-Vasodilator Agents
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
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pubmed:affiliation |
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1083, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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