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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1998-2-24
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pubmed:abstractText |
Intravenous administration of 2 micrograms/kg CCK-8 increased the single unit activity of 54% of hepatic vagal afferent fibers. Conduction velocity tests indicated that all of these units were C fibers. The increase in hepatic vagal activity produced by CCK-8 was significantly reduced by i.v. administration of 200 micrograms/kg of the CCKA receptor antagonist devazepide. Control comparisons indicated that this reduction was not an artifact of tachyphylaxis resulting from repeated administration of CCK-8. Further, the inability of pretreatment with atropine and hexamethonium to reduce the increases in hepatic vagal activity produced by CCK-8 suggests that the latter effect was not secondary to changes in gastrointestinal motor function. These outcomes demonstrate that activation of CCKA receptors by CCK-8 increases hepatic vagal afferent activity and support the view that the duodenal satiety action of CCK is mediated by the hepatic branch.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepinones,
http://linkedlifedata.com/resource/pubmed/chemical/Devazepide,
http://linkedlifedata.com/resource/pubmed/chemical/Ganglionic Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Hexamethonium,
http://linkedlifedata.com/resource/pubmed/chemical/Hormone Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cholecystokinin A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholecystokinin,
http://linkedlifedata.com/resource/pubmed/chemical/Sincalide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
776
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9439812-Animals,
pubmed-meshheading:9439812-Atropine,
pubmed-meshheading:9439812-Benzodiazepinones,
pubmed-meshheading:9439812-Devazepide,
pubmed-meshheading:9439812-Electrophysiology,
pubmed-meshheading:9439812-Ganglionic Blockers,
pubmed-meshheading:9439812-Hexamethonium,
pubmed-meshheading:9439812-Hormone Antagonists,
pubmed-meshheading:9439812-Liver,
pubmed-meshheading:9439812-Male,
pubmed-meshheading:9439812-Nerve Fibers,
pubmed-meshheading:9439812-Neurons, Afferent,
pubmed-meshheading:9439812-Parasympatholytics,
pubmed-meshheading:9439812-Rats,
pubmed-meshheading:9439812-Rats, Sprague-Dawley,
pubmed-meshheading:9439812-Receptor, Cholecystokinin A,
pubmed-meshheading:9439812-Receptors, Cholecystokinin,
pubmed-meshheading:9439812-Satiation,
pubmed-meshheading:9439812-Sincalide,
pubmed-meshheading:9439812-Vagus Nerve
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pubmed:year |
1997
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pubmed:articleTitle |
CCK-8 activates hepatic vagal C-fiber afferents.
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pubmed:affiliation |
Department of Psychology, University of Alabama at Birmingham 35294, USA. sbsf008@uabdpo.dpo.uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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