|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-1-20
|
|
pubmed:abstractText |
Insulin-stimulated DNA synthesis, MAP kinase (MAPK) activity and c-fos expression in vascular smooth muscle cells (VSMCs) was blocked by the MAPK inhibitor PD 98059. Regulation of c-fos expression by the transcription factor Elk-1 at the serum response element (SRE) is dependent on its phosphorylation by MAPK. PD 98059 also suppressed insulin-induced Elk-1 transcriptional activity through the SRE. These data show that MAPK plays a critical role in both insulin-mediated growth and Elk-1-dependent induction of c-fos in VSMCs.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Elk1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ets-Domain Protein Elk-1
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
417
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
283-6
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9409734-Animals,
pubmed-meshheading:9409734-Aorta, Thoracic,
pubmed-meshheading:9409734-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9409734-Cells, Cultured,
pubmed-meshheading:9409734-DNA-Binding Proteins,
pubmed-meshheading:9409734-Enzyme Activation,
pubmed-meshheading:9409734-Enzyme Inhibitors,
pubmed-meshheading:9409734-Flavonoids,
pubmed-meshheading:9409734-Genes, fos,
pubmed-meshheading:9409734-Insulin,
pubmed-meshheading:9409734-Muscle, Smooth, Vascular,
pubmed-meshheading:9409734-Proto-Oncogene Proteins,
pubmed-meshheading:9409734-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:9409734-RNA, Messenger,
pubmed-meshheading:9409734-Rats,
pubmed-meshheading:9409734-Rats, Sprague-Dawley,
pubmed-meshheading:9409734-Transcription, Genetic,
pubmed-meshheading:9409734-Transcription Factors,
pubmed-meshheading:9409734-Transcriptional Activation,
pubmed-meshheading:9409734-ets-Domain Protein Elk-1
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells.
|
|
pubmed:affiliation |
University of California, Los Angeles, School of Medicine 90024, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
