Linked Life Data

9409517

Source:http://linkedlifedata.com/resource/pubmed/id/9409517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-2-4
pubmed:abstractText
65Zn is one of the induced radioactive nuclides which are generated in power reactors. In the present experiment, several parameters of 65Zn metabolism were studied in mice maintained on diets with various zinc contents from 45 to 4,500 mg/kg to evaluate the efficacy of the dilution method for radiation protection against internal contamination with 65Zn. Gastrointestinal absorption of 65Zn was suppressed and its excretion accelerated as the dietary zinc content increased over a wide range. Clearance of 65Zn from tissues was generally accelerated by feeding mice a high-zinc diet, but that from the femurs was not affected by dietary zinc content. Zinc concentrations in tissues were regulated homeostatically up to a dietary zinc content of 1,350 mg/kg. Although a significant accumulation of zinc occurred in the liver, pancreas, kidneys, and femurs when mice were given 4,500 mg/kg diet, the concentrations except in the femurs recovered within a few days after switching to a normal-zinc diet. These results suggest that oral administration of zinc is effective for preventing the absorption and for enhancing the excretion of 65Zn to protect the body from internal radiation exposure with this isotope.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0916-7250
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1017-21
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of dietary zinc content on 65Zn metabolism in mice.
pubmed:affiliation
Faculty of Agriculture, Iwate University, Morioka, Japan.
pubmed:publicationType
Journal Article