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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-12-29
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pubmed:abstractText |
Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a wide variety of apoptotic and necrotic stimuli induce progressive mitochondrial swelling and outer mitochondrial membrane rupture. Discontinuity of the outer mitochondrial membrane results in cytochrome c redistribution from the intermembrane space to the cytosol followed by subsequent inner mitochondrial membrane depolarization. The mitochondrial membrane protein Bcl-xL can inhibit these changes in cells treated with apoptotic stimuli. In addition, Bcl-xL-expressing cells adapt to growth factor withdrawal or staurosporine treatment by maintaining a decreased mitochondrial membrane potential. Bcl-xL expression also prevents mitochondrial swelling in response to agents that inhibit oxidative phosphorylation. These data suggest that Bcl-xL promotes cell survival by regulating the electrical and osmotic homeostasis of mitochondria.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
627-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9393856-Anti-Bacterial Agents,
pubmed-meshheading:9393856-Antimycin A,
pubmed-meshheading:9393856-Apoptosis,
pubmed-meshheading:9393856-B-Lymphocytes,
pubmed-meshheading:9393856-Cytochrome c Group,
pubmed-meshheading:9393856-Flow Cytometry,
pubmed-meshheading:9393856-Gene Expression,
pubmed-meshheading:9393856-Homeostasis,
pubmed-meshheading:9393856-Humans,
pubmed-meshheading:9393856-Intracellular Membranes,
pubmed-meshheading:9393856-Jurkat Cells,
pubmed-meshheading:9393856-Membrane Potentials,
pubmed-meshheading:9393856-Microscopy, Electron,
pubmed-meshheading:9393856-Mitochondria,
pubmed-meshheading:9393856-Mitochondrial Swelling,
pubmed-meshheading:9393856-Oxidative Phosphorylation,
pubmed-meshheading:9393856-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9393856-Transfection,
pubmed-meshheading:9393856-bcl-X Protein
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pubmed:year |
1997
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pubmed:articleTitle |
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
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pubmed:affiliation |
Gwen Knapp Center and Committee on Immunology, Department of Medicine, University of Chicago, Illinois 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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