Linked Life Data

9389169

Source:http://linkedlifedata.com/resource/pubmed/id/9389169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-1-27
pubmed:abstractText
The arginine vasopressin (AVP) released from rat hypothalamic slices containing paraventricular and supraoptic nuclei sectioned with vibratome and incubated in microchambers was measured by radioimmunoassay. The effect of bovine serum albumin-conjugated corticosterone (B-BSA) on the AVP release was investigated. The results were as follows: (1) B-BSA, within 20 min, inhibited the AVP release in a dose-dependent manner from 10(-7) to 10(-4) mol/L. (2) The inhibitory effect of B-BSA was partially blocked by RU486 (10(-4)-10(-3) mol/L). (3) With the elevation of Ca2+ in the incubation medium the inhibitory effect of B-BSA was enhanced. (4) The inhibitory effect of B-BSA was also enhanced in the presence of neomycin (10(-3)-10(-2) mol/L). These results suggested that glucocorticoid, without entering into cells, could inhibit AVP release from rat hypothalamic slices. This effect might be mediated via a non-genomic mechanism involving a change of Ca2+ influx across the cell membrane.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Bovine serum albumin-conjugated corticosterone inhibits the release of arginine vasopressin].
pubmed:affiliation
Department of Physiology, Second Military Medical University, Shanghai.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't