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rdf:type |
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lifeskim:mentions |
umls-concept:C0021755,
umls-concept:C0037083,
umls-concept:C0086282,
umls-concept:C0127400,
umls-concept:C0205107,
umls-concept:C0663246,
umls-concept:C1334134,
umls-concept:C1363844,
umls-concept:C1417530,
umls-concept:C1706329,
umls-concept:C1708448,
umls-concept:C1710082
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pubmed:issue |
5343
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pubmed:dateCreated |
1997-12-18
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pubmed:databankReference |
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pubmed:abstractText |
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/pll protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1612-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9374458-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9374458-Amino Acid Sequence,
pubmed-meshheading:9374458-Antigens, Differentiation,
pubmed-meshheading:9374458-Carrier Proteins,
pubmed-meshheading:9374458-Cell Line,
pubmed-meshheading:9374458-Drosophila Proteins,
pubmed-meshheading:9374458-Humans,
pubmed-meshheading:9374458-Interleukin-1,
pubmed-meshheading:9374458-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:9374458-Molecular Sequence Data,
pubmed-meshheading:9374458-Myeloid Differentiation Factor 88,
pubmed-meshheading:9374458-NF-kappa B,
pubmed-meshheading:9374458-Protein Kinases,
pubmed-meshheading:9374458-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9374458-Proteins,
pubmed-meshheading:9374458-Receptors, Immunologic,
pubmed-meshheading:9374458-Receptors, Interleukin-1,
pubmed-meshheading:9374458-Sequence Alignment,
pubmed-meshheading:9374458-Sequence Homology, Amino Acid,
pubmed-meshheading:9374458-Signal Transduction,
pubmed-meshheading:9374458-TNF Receptor-Associated Factor 6,
pubmed-meshheading:9374458-Transfection
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pubmed:year |
1997
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pubmed:articleTitle |
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
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pubmed:affiliation |
University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article
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