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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-11-25
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pubmed:abstractText |
Cartilage is an avascular tissue, and exhibits anti-angiogenic properties. Cartilage extracts have been shown to contain an inhibitor for DNA synthesis in vascular endothelial cells in vitro. Here we purified the inhibitory activity in the 10-50 kDa fraction of guanidine extracts from fetal bovine epiphyseal cartilage, and found that the inhibitor was identical with chondromodulin-I (ChM-I). Purified ChM-I inhibited tube morphogenesis of cultured vascular endothelial cells, as well as DNA synthesis. These results indicate that cartilage-specific glycoprotein ChM-I may participate in the maintenance of avascularity and anti-angiogenic properties of cartilage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
415
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9357992-Animals,
pubmed-meshheading:9357992-Carotid Arteries,
pubmed-meshheading:9357992-Cattle,
pubmed-meshheading:9357992-Cell Size,
pubmed-meshheading:9357992-Cells, Cultured,
pubmed-meshheading:9357992-Chromatography, Affinity,
pubmed-meshheading:9357992-Chromatography, Gel,
pubmed-meshheading:9357992-DNA,
pubmed-meshheading:9357992-Dose-Response Relationship, Drug,
pubmed-meshheading:9357992-Endothelium, Vascular,
pubmed-meshheading:9357992-Glycoproteins,
pubmed-meshheading:9357992-Growth Plate,
pubmed-meshheading:9357992-Growth Substances,
pubmed-meshheading:9357992-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9357992-Morphogenesis,
pubmed-meshheading:9357992-Neovascularization, Physiologic,
pubmed-meshheading:9357992-Nucleic Acid Synthesis Inhibitors,
pubmed-meshheading:9357992-Thymidine
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pubmed:year |
1997
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pubmed:articleTitle |
Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I.
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pubmed:affiliation |
Department of Biochemistry, Osaka University Faculty of Dentistry, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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