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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-11-13
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pubmed:abstractText |
Altered gene expression occurs in the brain after global ischemia. We have developed a model to examine the effects of cardiopulmonary bypass and hypothermic circulatory arrest (HCA) on the induction of the immediate-early gene c-fos in the brains of neonatal lambs. We then tested the effects of the noncompetitive N-methyl-D-aspartate antagonist, aptiganel hydrochloride (Cerestat), on c-fos expression and neuronal injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-7; discussion 1088
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9354532-Animals,
pubmed-meshheading:9354532-Animals, Newborn,
pubmed-meshheading:9354532-Cardiopulmonary Bypass,
pubmed-meshheading:9354532-Cell Death,
pubmed-meshheading:9354532-Gene Expression,
pubmed-meshheading:9354532-Genes, fos,
pubmed-meshheading:9354532-Guanidines,
pubmed-meshheading:9354532-Heart Arrest, Induced,
pubmed-meshheading:9354532-Hippocampus,
pubmed-meshheading:9354532-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:9354532-RNA, Messenger,
pubmed-meshheading:9354532-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9354532-Sheep
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pubmed:year |
1997
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pubmed:articleTitle |
Immediate-early gene expression in ovine brain after hypothermic circulatory arrest: effects of aptiganel.
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pubmed:affiliation |
Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Ohio 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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