| pubmed-article:9341768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9341768 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:9341768 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9341768 | pubmed:dateCreated | 1997-11-14 | lld:pubmed |
| pubmed-article:9341768 | pubmed:abstractText | We recently showed, using human Jurkat T cell variants lacking the T cell receptor (TCR)/CD3 complex, that the lectin jacalin is able to trigger intracellular calcium increase provided that CD4 is expressed on the cell surface. Involvement of the CD4 molecule in jacalin-induced biological effects was furthermore demonstrated in differentiated U937 myelomonocytic cells expressing or not expressing CD4, and is confirmed here in human CD4-transfected mouse thymoma cells. In the present paper, we analyze the CD4-associated calcium response triggered by jacalin independently of the TCR/CD3 complex. We show that the observed calcium rise results from a direct long-lasting calcium influx from the outside without release of calcium from intracellular stores. We demonstrate that it is independent of the phosphoinositide phospholipase C transduction pathway. Moreover, we show that this peculiar calcium response can be blocked by protein tyrosine kinase inhibitors (herbimycin and genistein) giving evidence of the involvement of a protein tyrosine kinase, the best candidate of which is the CD4-associated p56lck. Altogether, our results suggest that, independently of the TCR/CD3 complex, CD4 may be involved in the triggering of a calcium signal dependent on a protein tyrosine kinase and independent of the phosphoinositide transduction pathway. | lld:pubmed |
| pubmed-article:9341768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9341768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9341768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9341768 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9341768 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:RouotBB | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:FischerTT | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:FaveroJJ | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:ZumbihlRR | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:HivrozCC | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:FaureSS | lld:pubmed |
| pubmed-article:9341768 | pubmed:author | pubmed-author:LafontVV | lld:pubmed |
| pubmed-article:9341768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9341768 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:9341768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9341768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9341768 | pubmed:pagination | 2261-8 | lld:pubmed |
| pubmed-article:9341768 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9341768 | pubmed:meshHeading | pubmed-meshheading:9341768-... | lld:pubmed |
| pubmed-article:9341768 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9341768 | pubmed:articleTitle | Evidence for a CD4-associated calcium influx independent of the phosphoinositide transduction pathway in human T cells. | lld:pubmed |
| pubmed-article:9341768 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale (INSERM) U431, Université de Montpellier II, France. | lld:pubmed |
| pubmed-article:9341768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9341768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
