Linked Life Data

9321707

Source:http://linkedlifedata.com/resource/pubmed/id/9321707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-11-18
pubmed:abstractText
When axons grow towards their targets, their tips form a specialized dynamic structure called the growth cone. To establish their orientation, growth cones continuously explore their local environment for guidance information. The growth cone sensor for immobilized signals displayed on the surface of cells or in the extracellular matrix is a multimolecular complex of surface molecules, signaling molecules and cytoskeletal components. Axonin-1 and neuron-glia cell-adhesion molecule (NgCAM) are thought to play an important role as surface-expressed "recognition" components of the pathway sensor of the growth cones in a number of neuronal populations of the peripheral and central nervous systems. Both molecules are capable of specifically binding a number of other extracellular molecules and cluster at the substratum contact area of the growth cone, when the substratum contains axonin-1 or NgCAM. Recent results indicate that axonin-1 and NgCAM interact in the plane of the growth cone membrane and that their clustering is associated with a change in the associated intracellular signals. The present review summarizes the recent developments of the concept that different clusters of axonin-1 and NgCAM at growth cone/substratum contacts elicit different intracellular signals in growth cones and eventually determine the pathway choice of the growth cone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0302-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-39
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Axonin-1 and NgCAM as "recognition" components of the pathway sensor apparatus of growth cones: a synopsis.
pubmed:affiliation
Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. pson@bioc.unizh.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't