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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0026764,
umls-concept:C0032131,
umls-concept:C0033684,
umls-concept:C0040300,
umls-concept:C0174680,
umls-concept:C0205155,
umls-concept:C0231441,
umls-concept:C0443218,
umls-concept:C1441616,
umls-concept:C1522472,
umls-concept:C1551341,
umls-concept:C1552858,
umls-concept:C1552923,
umls-concept:C1552924,
umls-concept:C1705191,
umls-concept:C2603343,
umls-concept:C2827483
|
| pubmed:issue |
9
|
| pubmed:dateCreated |
1997-11-6
|
| pubmed:abstractText |
In this study, we analyzed 69 plasma cell neoplasms, including 54 multiple myelomas (MMs), 3 cases of plasma cell leukemia, and 12 plasmacytomas, for expression of cyclin D1 protein using an immuno-histochemical method applied to routinely fixed, paraffin-embedded tissue sections. Cyclin D1 was expressed in 18 (26%) of 69 plasma cell neoplasms, including 16 (30%) of 54 MMs and 2 (17%) of 12 plasmacytomas. Three cases of plasma cell leukemia were negative. Cyclin D1 expression correlated with the cytologic differentiation and histologic stage of MM. Twelve (75%) of 16 MMs had intermediate or immature cytologic features and were histologic Stage III. With use of a polymerase chain reaction assay, we also analyzed six cases (three cyclin D1 positive, three cyclin D1 negative) for the t(11;14); one MM carried the t(11;14) and expressed cyclin D1 protein. We conclude that cyclin D1 expression occurs in approximately one-quarter of plasma cell neoplasms and correlates with the degree of cytologic differentiation and histologic stage. The relatively high frequency of cyclin D1 expression, compared with the less than 5% incidence of the t(11;14) detected by conventional cytogenetics reported in the literature, suggests that upregulation of cyclin D1 protein might be the result of mechanisms other than the t(11;14).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0893-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
927-32
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9310957-Adult,
pubmed-meshheading:9310957-Aged,
pubmed-meshheading:9310957-Aged, 80 and over,
pubmed-meshheading:9310957-Cyclin D1,
pubmed-meshheading:9310957-Female,
pubmed-meshheading:9310957-Humans,
pubmed-meshheading:9310957-Immunoglobulin Heavy Chains,
pubmed-meshheading:9310957-Immunoglobulin Light Chains,
pubmed-meshheading:9310957-Immunohistochemistry,
pubmed-meshheading:9310957-Leukemia, Plasma Cell,
pubmed-meshheading:9310957-Male,
pubmed-meshheading:9310957-Middle Aged,
pubmed-meshheading:9310957-Multiple Myeloma,
pubmed-meshheading:9310957-Paraffin Embedding,
pubmed-meshheading:9310957-Plasmacytoma,
pubmed-meshheading:9310957-Polymerase Chain Reaction,
pubmed-meshheading:9310957-Survival Rate
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.
|
| pubmed:affiliation |
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
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| pubmed:publicationType |
Journal Article
|