| pubmed-article:9298486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0019144 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0439792 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9298486 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9298486 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9298486 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9298486 | pubmed:abstractText | Liver regeneration is a physiological mechanism that leads to restoration of the hepatic parenchyma following hepatectomy or toxic injury. As a two-third hepatectomy is the usual model to analyse this phenomenon, few studies have compared liver regeneration after minor vs major hepatectomy. We have used a quantitative RT-PCR technique to study the hepatic transcription of the TGF-alpha gene in rats submitted to 30% or 80% hepatectomy and we have correlated this transcription with the regenerative response assessed by flow cytometry and Ki-67 expression. The level of TGF-alpha expression and the regenerative response were different, according to the volume of liver removed, and were statistically correlated (r = 0.679, p = 0.002). TGF-alpha expression and phase S peaked at day 2 vs 6 in the 80% vs 30% hepatectomized rat groups, respectively. Ki-67 expression occurred at 2 h post-hepatectomy in the two groups of rats and was observed until day 14 mainly in the 80% hepatectomy group. Our results indicate that TGF-alpha expression in regenerating liver is strongly correlated with hepatocyte mitosis, that a delayed regenerative response occurs following 30% hepatectomy and that the course of regeneration differs between minor vs major hepatectomy. | lld:pubmed |
| pubmed-article:9298486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9298486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9298486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9298486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9298486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9298486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9298486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9298486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9298486 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9298486 | pubmed:issn | 0106-9543 | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:LebretonJ PJP | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:HironMM | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:DaveauMM | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:HémetJJ | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:TénièrePP | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:MassonSS | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:LaquerrièreAA | lld:pubmed |
| pubmed-article:9298486 | pubmed:author | pubmed-author:ScottéMM | lld:pubmed |
| pubmed-article:9298486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9298486 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9298486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9298486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9298486 | pubmed:pagination | 171-6 | lld:pubmed |
| pubmed-article:9298486 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
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| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:meshHeading | pubmed-meshheading:9298486-... | lld:pubmed |
| pubmed-article:9298486 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9298486 | pubmed:articleTitle | Transforming growth factor alpha (TGF-alpha) expression correlates with DNA replication in regenerating rat liver whatever the hepatectomy extent. | lld:pubmed |
| pubmed-article:9298486 | pubmed:affiliation | INSERM U 78 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides Bois-Guillaume, France. | lld:pubmed |
| pubmed-article:9298486 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9298486 | lld:pubmed |
