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pubmed-article:9287222pubmed:abstractTextThe cell division cycle gene, CDC34, is required for ubiquitin-mediated degradation of G1 regulators and cell cycle progression through the transition from G1 to S phase in budding yeast. A CDC34 requirement for S phase onset in higher eukaryotes has not been established. Studies of the simple embryonic cell cycle of Xenopus laevis eggs demonstrated that Cdc34p in a large molecular size complex was required in the initiation of DNA replication. Cdc34p appears to regulate the initiation function of Cdk2-cyclin E, perhaps through the degradation of the Xenopus cdk inhibitor, Xic1.lld:pubmed
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pubmed-article:9287222pubmed:articleTitleProteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.lld:pubmed
pubmed-article:9287222pubmed:affiliationDepartment of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.lld:pubmed
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