|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1997-11-18
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Mammalian voltage-gated K channel genes have been divided into four subfamilies (Shaker, Shab, Shal, and Shaw) based on their sequence identity and similarity to related genes in Drosophila. Genetic mapping of the voltage-gated K channel genes has shown that similar multigene clusters exist on mouse Chr 3 and 6 and suggests that the clusters may have arisen through chromosomal duplication. In this report, YAC-based physical maps of the clustered mouse Shaker-like K channel genes have been constructed using restriction endonuclease and yeast chromosome fragmentation approaches. These data define the physical spacing as 5'-Kcna3-(60 kb)-Kcna2-(90 kb)-Kcna8-3' on Chr 3, and as 5'-Kcna6-(80 kb)-Kcna1-(110 kb)-Kcna5-3' on Chr 6, with all genes oriented in a head-to-tail manner within their respective clusters. These detailed physical maps of both K channel gene clusters provide additional support for the idea of an ancient genome tetraploidization event.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0888-7543
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
110-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9286706-Animals,
pubmed-meshheading:9286706-Chromosomes, Artificial, Yeast,
pubmed-meshheading:9286706-Cloning, Molecular,
pubmed-meshheading:9286706-DNA Probes,
pubmed-meshheading:9286706-Drosophila,
pubmed-meshheading:9286706-Drosophila Proteins,
pubmed-meshheading:9286706-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:9286706-Evolution, Molecular,
pubmed-meshheading:9286706-Genetic Linkage,
pubmed-meshheading:9286706-Ion Channel Gating,
pubmed-meshheading:9286706-Mice,
pubmed-meshheading:9286706-Molecular Sequence Data,
pubmed-meshheading:9286706-Multigene Family,
pubmed-meshheading:9286706-Polymerase Chain Reaction,
pubmed-meshheading:9286706-Potassium Channels,
pubmed-meshheading:9286706-Restriction Mapping,
pubmed-meshheading:9286706-Sequence Homology, Amino Acid,
pubmed-meshheading:9286706-Shaker Superfamily of Potassium Channels,
pubmed-meshheading:9286706-Transcription, Genetic
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Physical mapping of potassium channel gene clusters on mouse chromosomes three and six.
|
|
pubmed:affiliation |
Department of Otolaryngology/Head and Neck Surgery, University of Washington School of Medicine, Seattle 98195, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
