| pubmed-article:9284322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9284322 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:9284322 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:9284322 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9284322 | pubmed:dateCreated | 1997-10-20 | lld:pubmed |
| pubmed-article:9284322 | pubmed:abstractText | The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures. | lld:pubmed |
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| pubmed-article:9284322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9284322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9284322 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9284322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9284322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9284322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9284322 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9284322 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:9284322 | pubmed:author | pubmed-author:BalAA | lld:pubmed |
| pubmed-article:9284322 | pubmed:author | pubmed-author:PalDD | lld:pubmed |
| pubmed-article:9284322 | pubmed:author | pubmed-author:Sundaralingam... | lld:pubmed |
| pubmed-article:9284322 | pubmed:author | pubmed-author:WahlM CMC | lld:pubmed |
| pubmed-article:9284322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9284322 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:9284322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9284322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9284322 | pubmed:pagination | 1553-61 | lld:pubmed |
| pubmed-article:9284322 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9284322 | pubmed:meshHeading | pubmed-meshheading:9284322-... | lld:pubmed |
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| pubmed-article:9284322 | pubmed:meshHeading | pubmed-meshheading:9284322-... | lld:pubmed |
| pubmed-article:9284322 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9284322 | pubmed:articleTitle | Crystal structure of d(GCGCGCG) with 5'-overhang G residues. | lld:pubmed |
| pubmed-article:9284322 | pubmed:affiliation | Biological Macromolecular Structure Center, Department of Chemistry, The Ohio State University, Columbus 43210-1002, USA. | lld:pubmed |
| pubmed-article:9284322 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9284322 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9284322 | lld:pubmed |
