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pubmed-article:9256134pubmed:abstractTextThe camptothecin derivative irinotecan has demonstrated clinical activity in metastatic colorectal carcinoma in both chemotherapy-naive and fluorouracil-refractory patients. 9-Aminocamptothecin (9-AC; NSC 603071), another camptothecin derivative, was selected for clinical development based on preclinical activity, including cures in human tumor xenografts resistant to standard anticancer agents. We report a phase II trial of 9-AC in patients with previously untreated metastatic colorectal carcinoma.lld:pubmed
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pubmed-article:9256134pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9256134pubmed:year1997lld:pubmed
pubmed-article:9256134pubmed:articleTitlePhase II trial of 9-aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma.lld:pubmed
pubmed-article:9256134pubmed:affiliationDepartment of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. rpazdur@notes.mdacc.tmc.edulld:pubmed
pubmed-article:9256134pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9256134pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:9256134pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9256134pubmed:publicationTypeClinical Trial, Phase IIlld:pubmed
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