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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1997-9-8
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pubmed:abstractText |
The camptothecin derivative irinotecan has demonstrated clinical activity in metastatic colorectal carcinoma in both chemotherapy-naive and fluorouracil-refractory patients. 9-Aminocamptothecin (9-AC; NSC 603071), another camptothecin derivative, was selected for clinical development based on preclinical activity, including cures in human tumor xenografts resistant to standard anticancer agents. We report a phase II trial of 9-AC in patients with previously untreated metastatic colorectal carcinoma.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
pubmed:issn |
0732-183X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2905-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9256134-Adenocarcinoma,
pubmed-meshheading:9256134-Adult,
pubmed-meshheading:9256134-Aged,
pubmed-meshheading:9256134-Antineoplastic Agents,
pubmed-meshheading:9256134-Camptothecin,
pubmed-meshheading:9256134-Colorectal Neoplasms,
pubmed-meshheading:9256134-Drug Administration Schedule,
pubmed-meshheading:9256134-Female,
pubmed-meshheading:9256134-Humans,
pubmed-meshheading:9256134-Infusion Pumps,
pubmed-meshheading:9256134-Infusions, Intravenous,
pubmed-meshheading:9256134-Male,
pubmed-meshheading:9256134-Middle Aged
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pubmed:year |
1997
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pubmed:articleTitle |
Phase II trial of 9-aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma.
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pubmed:affiliation |
Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. rpazdur@notes.mdacc.tmc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Clinical Trial, Phase II
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