| pubmed-article:9252034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0003123 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0043096 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C2936302 | lld:lifeskim |
| pubmed-article:9252034 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:9252034 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9252034 | pubmed:dateCreated | 1997-9-24 | lld:pubmed |
| pubmed-article:9252034 | pubmed:abstractText | Pro-inflammatory cytokines produced in the central nervous system (CNS) have been suggested to have a role in the anorexia and cachexia of disease. In the present study, the effects of chronic exposure of the CNS to interleukin-1beta (IL-1beta) on several indicators of cachexia were studied. Rats were prepared with an intracerebroventricular (i.c.v.) cannula and an osmotic minipump that delivered vehicle or 1.56 ng/h recombinant murine IL-1beta for 4 days. Food intake and body weight were determined daily during the 4-day infusion period and plasma IL-6 and corticosterone concentrations were determined from plasma collected postinfusion. Chronic i.c.v. infusion of IL-1beta resulted in a chronic reduction in food intake. Rats infused i.c.v. with IL-1beta ate less food each day compared to vehicle controls and, at the end of the 4-day infusion period, consumed an average of 17.2 g less. Intracerebroventricular infusion of IL-1beta also caused an immediate and substantial loss of body weight that was sustained throughout the infusion period. In addition, rats infused with IL-1beta had plasma levels of IL-6 double those of vehicle controls (401 pg/ml vs. 185 pg/ml). Plasma corticosterone concentrations were similar between treatments. These results suggest that chronic exposure of the CNS to cytokines such as IL-1beta may be sufficient to induce anorexia and cachexia. | lld:pubmed |
| pubmed-article:9252034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9252034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9252034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9252034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9252034 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9252034 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9252034 | pubmed:author | pubmed-author:JohnsonR WRW | lld:pubmed |
| pubmed-article:9252034 | pubmed:author | pubmed-author:FinckB NBN | lld:pubmed |
| pubmed-article:9252034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9252034 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9252034 | pubmed:volume | 761 | lld:pubmed |
| pubmed-article:9252034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9252034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9252034 | pubmed:pagination | 333-7 | lld:pubmed |
| pubmed-article:9252034 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:meshHeading | pubmed-meshheading:9252034-... | lld:pubmed |
| pubmed-article:9252034 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9252034 | pubmed:articleTitle | Anorexia, weight loss and increased plasma interleukin-6 caused by chronic intracerebroventricular infusion of interleukin-1beta in the rat. | lld:pubmed |
| pubmed-article:9252034 | pubmed:affiliation | Department of Animal Sciences, University of Illinois, Urbana 61801, USA. | lld:pubmed |
| pubmed-article:9252034 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9252034 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9252034 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9252034 | lld:pubmed |
