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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-8-8
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pubmed:databankReference | |
pubmed:abstractText |
SHV-6 was previously identified by its susceptibility pattern and biochemical criteria in a clinical isolate of Klebsiella pneumoniae which was resistant to ceftazidime. It contains only a single point difference with the beta laSHV-1 gene as determined by PCR amplification and nucleotide sequencing. This is the result of a single amino acid substitution, Ala for Asp, at position 179. Directed mutagenesis experiments have shown this substitution to confer selective resistance to ceftazidime in the TEM family.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0378-1097
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-7
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:9228783-Amino Acid Sequence,
pubmed-meshheading:9228783-Base Sequence,
pubmed-meshheading:9228783-Ceftazidime,
pubmed-meshheading:9228783-Klebsiella pneumoniae,
pubmed-meshheading:9228783-Microbial Sensitivity Tests,
pubmed-meshheading:9228783-Molecular Sequence Data,
pubmed-meshheading:9228783-Structure-Activity Relationship,
pubmed-meshheading:9228783-beta-Lactamases
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pubmed:year |
1997
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pubmed:articleTitle |
Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum beta-lactamase.
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pubmed:affiliation |
Université Paris VII Denis Diderot, Service de Microbiologie, Hôpital Saint-Louis, Paris, France.
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pubmed:publicationType |
Journal Article
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