| pubmed-article:9203989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0549206 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0748342 | lld:lifeskim |
| pubmed-article:9203989 | lifeskim:mentions | umls-concept:C0556096 | lld:lifeskim |
| pubmed-article:9203989 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9203989 | pubmed:dateCreated | 1997-7-15 | lld:pubmed |
| pubmed-article:9203989 | pubmed:abstractText | Hypercalciuria may be a contributory factor to the disturbed calcium homoeostasis seen in diabetic pregnant rats and their offspring. In diabetes, essential fatty acid metabolism is impaired. We have therefore investigated whether feeding a diet supplemented with essential fatty acids will ameliorate the hypercalciuria of diabetic pregnancy and improve reproductive performance. Female rats were fed a standard rat diet, a fat-free diet plus evening primrose oil or a fat-free diet plus sunflower oil. They were injected with streptozotocin or vehicle and mated. Urine samples were analysed for calcium before injection and during gestation. Term-pregnant diabetic rats fed evening primrose oil showed a 73% reduction in urinary calcium output compared with similar rats fed standard diet (P < 0.001). The corresponding reduction was 44% in diabetic rats fed sunflower oil (P < 0.001). A depletion of essential fatty acids in diabetes may therefore be associated with hypercalciuria; dietary supplementation, particularly with evening primrose oil, appears to correct the problem. Diabetic pregnant rats fed evening primrose oil showed a significantly greater live fetal mass (85 +/- 2 vs 33 +/- 12 g; P < 0.05) compared with similar rats fed standard diet. Such findings may imply a normalization of placental transport by essential fatty acids. Rats fed evening primrose, but not sunflower oil, also showed a reduced incidence of diabetes after streptozotocin injection compared with rats fed standard diet (63 vs 86%). Rats fed on evening primrose oil that did become diabetic were less hyperglycaemic than those on the standard diet (29 +/- 2 vs 37 +/- 2 mmol/l), suggesting that the oil may have anti-diabetic properties. | lld:pubmed |
| pubmed-article:9203989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9203989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9203989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9203989 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9203989 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:9203989 | pubmed:author | pubmed-author:SibleyC PCP | lld:pubmed |
| pubmed-article:9203989 | pubmed:author | pubmed-author:GarlandH OHO | lld:pubmed |
| pubmed-article:9203989 | pubmed:author | pubmed-author:ForshawA GAG | lld:pubmed |
| pubmed-article:9203989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9203989 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:9203989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9203989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9203989 | pubmed:pagination | 357-63 | lld:pubmed |
| pubmed-article:9203989 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9203989 | pubmed:meshHeading | pubmed-meshheading:9203989-... | lld:pubmed |
| pubmed-article:9203989 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9203989 | pubmed:articleTitle | Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. | lld:pubmed |
| pubmed-article:9203989 | pubmed:affiliation | School of Biological Sciences, University of Manchester, UK. | lld:pubmed |
| pubmed-article:9203989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9203989 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9203989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
