| pubmed-article:9199490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9199490 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:9199490 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:9199490 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9199490 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:9199490 | pubmed:dateCreated | 1997-7-21 | lld:pubmed |
| pubmed-article:9199490 | pubmed:abstractText | We have evaluated the effect of intraperitoneal (I.P.) injection of human recombinant interferon-2alpha (IFN-alpha) on Bleomycin-induced pulmonary injury in hamsters. Pulmonary injury was induced by a single intratracheal (I.T.) instillation of Bleomycin (Bleo). Six groups of male Syrian hamsters were treated as follows: 1) I.T. Bleo and daily I.P. injections of low-dose interferon-alpha (2 x 10(4) U), 2) I.T. Bleo and daily I.P. injections of high-dose interferon-alpha (10(5) U), 3) I.T. Bleo and I.P. injections of saline, 4) I.T. saline and I.P. low-dose IFN-alpha, 5) I.T. saline and I.P. high-dose IFN-alpha, 6) I.T. saline and I.P. saline. Animals were sacrificed 28 days after I.T. treatment. Lung injury was evaluated histologically and biochemically. Treatment of hamsters with low-dose but not high-dose IFN-alpha significantly augmented the Bleo-induced lung injury, as determined by a semiquantitative morphological index. Lung hydroxyproline measurements were highest in Bleo-low-dose-IFN-alpha followed by Bleo-high-dose-IFN-alpha and Bleo-Sal as compared to Sal-Sal and Sal-IFN-alpha controls. These results suggest that IFN-alpha augments Bleo-induced lung injury but that this effect is complex and does not follow a simple-dose-response pattern. | lld:pubmed |
| pubmed-article:9199490 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9199490 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9199490 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9199490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9199490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9199490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9199490 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:9199490 | pubmed:author | pubmed-author:GoldsteinR... | lld:pubmed |
| pubmed-article:9199490 | pubmed:author | pubmed-author:BerkmanNN | lld:pubmed |
| pubmed-article:9199490 | pubmed:author | pubmed-author:BreuerRR | lld:pubmed |
| pubmed-article:9199490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9199490 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:9199490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9199490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9199490 | pubmed:pagination | PL415-21 | lld:pubmed |
| pubmed-article:9199490 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:meshHeading | pubmed-meshheading:9199490-... | lld:pubmed |
| pubmed-article:9199490 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9199490 | pubmed:articleTitle | Bleomycin-induced lung injury is enhanced by interferon-alpha. | lld:pubmed |
| pubmed-article:9199490 | pubmed:affiliation | Pulmonary Cellular and Molecular Biology Laboratory, Institute of Pulmonology, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:9199490 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9199490 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
