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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-8-13
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pubmed:abstractText |
CD4 interacts with the immunoglobulin (Ig)-VH domains by a virtue of its solvent-exposed C and C strands. These two strands also contribute to the full HIV-gp120 binding and participate significantly in binding to class II MHC molecules. In this paper we hypothesize that any high-affinity interaction between serum (or membrane-expressed) Ig and CD4 may have impact on early T cell activation events. The existing data provide evidence for different outcomes of a high affinity Ig/CD4 interaction on T cell proliferation and cytokine secretion: costimulation and inhibition. We will also discuss how a low affinity CD4/Ig interaction could play an important role in B cell stimulation initiated through surface Ig receptors, and how CD4 may be involved in shaping the B cell repertoire.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0883-0185
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9186786-Animals,
pubmed-meshheading:9186786-Antigen-Antibody Complex,
pubmed-meshheading:9186786-Antigens, CD4,
pubmed-meshheading:9186786-B-Lymphocytes,
pubmed-meshheading:9186786-Binding Sites,
pubmed-meshheading:9186786-Humans,
pubmed-meshheading:9186786-Immunoglobulin Heavy Chains,
pubmed-meshheading:9186786-Immunoglobulin Variable Region,
pubmed-meshheading:9186786-Lymphocyte Activation,
pubmed-meshheading:9186786-Mice,
pubmed-meshheading:9186786-Mice, Knockout,
pubmed-meshheading:9186786-Staphylococcal Protein A,
pubmed-meshheading:9186786-Superantigens,
pubmed-meshheading:9186786-T-Lymphocytes
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pubmed:year |
1997
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pubmed:articleTitle |
Ig VH-dependent interaction between immunoglobulins and CD4.
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pubmed:affiliation |
Louis-Charles Simard Research Center, Notre-Dame Hospital, University of Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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